47 years old female presented with dryness of mouth (figures 1-3) with occasional slurring of speech and occasional dysphasia since last 4-5 years with dry eyes. Which syndrome is flashing on your mind? �

Role and interpretation of ANA in autoimmune disease. The antinuclear antibody (ANA) test is used as a primary test to help evaluate a person for autoimmune disease and is most often used as one of the tests to help diagnose systemic lupus erythematosus (SLE) along with various other tests. ANA are a group of autoantibodies produced by a person's immune system when it fails to adequately distinguish between "self" and "nonself." They target substances found in the nucleus of a cell and cause organ and tissue damage Different laboratories may use different test methods to detect ANA. Two common methods include immunoassay and indirect fluorescent antibody (IFA). IFA is considered the gold standard. Some laboratories will use immunoassay to screen for ANA and use IFA to confirm positive or equivocal results. Patterns of cellular fluorescence In addition to a titer, positive results on IFA will include a description of the particular type of fluorescent pattern seen. Different patterns have been associated with different autoimmune disorders, although some overlap may occur. Some of the more common patterns include: Homogenous (diffuse)—associated with SLE, mixed connective tissue disease, and drug-induced lupus Speckled—associated with SLE, Sjögren syndrome, scleroderma, polymyositis, rheumatoid arthritis, and mixed connective tissue disease Nucleolar—associated with scleroderma and polymyositis Centromere pattern (peripheral)—associated with scleroderma and CREST (Calcinosis, Raynaud syndrome, Esophogeal dysmotility, Sclerodactyly, Telangiectasia) hope this will be HELPFUL to all the collogues on Curofy.

25 yr female. 3yr /h/of. ..photosensitive malar rash. C/o Low grade fever on and off. Arthralgia. ..multiple joint pains . Nausea, diarrhoea with abdominal cramps. O/E. ..she had mouth and palatal ulcers Lab inv. .....hb 7.9, platelet. .2 97 000 Wbc. .5900, esr. .110 Anti dna strongly positive. Ur valuable comments. .

Pt. 53/F, C/O pain n jt stiffness in B/L hands n feet since 7-8 yrs. H/O chicken gunia fever 7-8 yrs ago. O/e, stiffness of MCP pIP n dIP jts of both hands. Ankle n MTP jts stiffness. Clinical pic n ixns attached. Advise, Dx n rx plz.

45 yr Female with chest pain on/off 3 months associated with cough . Generalized body pains +, Joint pains + Her chest x ray and CECT chest done. Autoimmune profile done. Reports attached. @Sandeep Ghodekar