A female patient of Membranoproliferative Glomerulonephritis has these retina lesions, identify them
Yes they are Basal Laminar Drusens in both eyes fundus associated with Membranoproliferative Glomerulonephritis
Extensive Drusen formation .
Drusens
LOOK LIKE CLUSTER OF SOFT MICRODRUSENS
Drusen.
Drusens
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same patient pics before and after treatment..what could be diagnosed and what treatment could given??
Dr. Kamal Thadhani3 Likes18 Answers - Login to View the image
WHAT IS MPGN Membranoproliferative glomerulonephritis (MPGN) is a disease that affects the glomeruli, or filters, of the kidneys. Most instances of MPGN are caused by other diseases or disorders, including autoimmune diseases (such as systemic lupus erythematosis), chronic infections (like hepatitis B or more commonly hepatitis C), monoclonal immunoglobulin deposition diseases, and hereditary diseases. However, a few cases are idiopathic, or of unknown cause. The idiopathic type of MPGN is seen more commonly in persons aged 8-40 MICROSCOPIC TYPES There are three histologic (microscopic) types of MPGN, each of which has a different appearance under the microscope. Type I– Discrete immune complexes are found in the mesangium and subendothelial space. Immune complexes are combinations of antigens and antibodies which bind to each other and then become lodged in the kidney. This activates the immune system, which causes inflammation and damage to the kidney itself. Type II – This is also called dense deposit disease. When viewed under the microscope, continuous, dense ribbon-like deposits are found along the basement membranes of the glomeruli, tubules, and Bowman’s capsule. Type III – This is also an immune complex disease, similar to Type I. However, the immune complexes are found in the subepithelial space, and there is disruption of the glomerular basement membrane with large open areas. What are the symptoms? The symptoms of MPGN are very similar to those of a focal glomerulonephritis. Specifically, patients have hematuria (blood in the urine), either macroscopic, which can be seen by the naked eye, or microscopic. Many of the red blood cells are dysmorphic (malformed or misshapen). In addition, mild or severe proteinuria can be found (including the nephrotic syndrome). What is the treatment? When MPGN is associated with another condition or disease, it is usually resolved by successfully treating the associated condition or disease. However, the optimal treatment of idiopathic MPGN is not entirely known. The type of treatment will depend on the type of proteinuria that the patient has. If a patient has proteinuria that is “non-nephrotic”, then specific immunosuppressive therapy may not be necessary, as the long-term outcome is not life-threatening. However, patients with nephrotic-range proteinuria will typically be treated with steroids (Prednisone).
Sushmita Haodijam2 Likes1 Answer - Login to View the image
A 66-year-old woman presents with three months of shortness of breath, left-sided ear pain, and hemoptysis. Her family history is significant for rheumatoid arthritis and multiple sclerosis. She has an allergy to sulfa. On examination, there is evidence of chronic sinusitis, palpable purpura in the lower extremities, and active arthritis in multiple joints. Laboratory findings are notable for an increased ESR, elevated creatinine, and a positive c-ANCA. A chest CT demonstrates the findings above. A referral is made for plasma exchange and immunosuppressive therapy. Which of the following is most appropriate for pneumocystis pneumonia prophylaxis? A) Trimethoprim-sulfamethoxazole B) Doxycycline C) Atovaquone D) Pentamidine
Dr. Somi Suyal3 Likes15 Answers - Login to View the image
Identify the marked area & characteristic of : A. Diabetic nephropathy B. Analgesic nephropathy C. RPGN D. Post streptococcal glomerulonephritis
Krishna Chakma1 Like19 Answers - Login to View the image
عزت وجدى 3 years old male Bl pr 99/75 mmhg Please for diagnosis and ttt Thanks
Dr. Abd Elnasser Badawy0 Like21 Answers