A Urgent Case of Thrombocytopenia , Expert Suggestions Required

24 Yr old female Having A measurable life With thrombocytopenia cause of which is still unknown Patient receive Platlet rich plasma Infusion twice but Platelets count keeps going down each day , doctors suggesting blood cancer What can be the Diagnostic set up .. Thrombocytopenia can be caused by Aplastic anaemia , Lupus , Blood cancer , lymphoma ..etc ..what we can do to investigate the root cause Chief Complaints Rashes on body comes and goes , Joint pain , Fatigue , Subcutaneous bleeding on scratching skin History Patient has hypothyroidism

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ITP is associated with thrombocytopenia, but other two cell lines - that is erythrocytes and leucocytes are normal In this case there is associated anemia, this raised possibility of other causes of thrombocytopenia 1) Infection - check for HIV, Malaria, Dengue, Leptospirosis 2) Hemolytic anemia - do coombs test to rule out Hemolytic anemia 3) Anti-nuclear Antibody test to rule out Autoimmune diseases 4) B 12 deficiency - do serum B 12 levels, as pernicious anemia can present with thrombocytopenia 5) Bone marrow aspiration and biopsy to look for bone marrow pathology

Thank you doctor
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WELCOME. DR. @ ABRAR. AHMED. KHAN. JI... SUGGESTIVE OF SEVERE. THROMBOCYTOPENIA/ PURPURA.... INDUCED. BY SEVERE HYPOTHYROIDISM "AUTO-ANTIBODIES. TO ..PLATELET. ANTIGENS.... HAVE. BEEN. SHOWN. . TO. CO-EXIST WITH AUTO-IMMUNE. THYROID DISEASE. "" ADVISABLE ..THYROID. HORMONAL THERAPY... ......AFTER. REVIEW. OF FREE. THYROID. HORMONES AND T S H... THIS. CONDITION....MAY. SHOW EXAMPLERY. IMPROVEMENT

NEED'S.. HISTOPATHOLOGICAL STUDY.. REGARDING.. DECREASED PLATELETS COUNT.. ? ITP ..

Tnx Dr Shivraj Agarwal sir
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C/o thrombocytopenia Bone marrow study needed ITP work up needed

Thanks@Shivraj Agarwal sir
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It appears to be a c/o ITP and should be processed in that way

Thanx dr Kute Ankush
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Mostly ITP...to do Bone marrow to rule out other causes...to do ANA day DNA...it can be 2ndary immune thrombocytopenia 2ndary to Collagen vascular disease..Anaemia Mostly Iron def...after Bone marrow. U can start inj MPS 1gm iv for 3 days followed by tb prednisolone 1mg/kg for 21days followed by taper prednisolone 5mg per week..then stop..along with prednisolone to give pan40 n calcium.. monitor blood sugar n BP

DD ITP following acute viral infection Unlikely to be bone marrow causes since RBC and WBC counts are near normal. HSP is DD, but unlikely because, there is no hematuria, or abdominal pain . Needs investigations for ITP . Needs STEROIDS urgently to tide over the crisis .

Its a case of ITP Know the cause of thrombocytopenia by doing mp antigen n dengue profile See of infectious Send anti body test Or see for iron profile Last see for bone morrow N treat accordingly

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