An 81 year old female with past medical history of coronary disease was found to have an incidental mass in the right kidney during an ultrasound performed for a recent elevated creatinine level. No previous history of chronic renal failure, hypertension or diabetes was reported. CT scan and an MRI showed a partially cystic, enhancing lower pole mass in the right kidney, measuring 2.8 cm in greatest dimension. Diagnose the slides of right partial nephrectomy specimen.

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and focally, there was a region with tubular and papillary architecture where the nuclei are aligned away from basement membrane, similar to the subnuclear vacuoles of early secretory endometrium.

Overall Morphology is favouring Clear cell Papillary Renal Cell Carcinoma ( subtype of Clear cell carcinoma)with variable Papillary , solid , cystic, Tubulopapillary components

Microscopic examination shows a solid and cystic neoplasia with solid, papillary and tubular architecture.

Clear cell carcinoma

The neoplastic cells shown in microscopic image have clear cytoplasm, small and bland nuclei with inconspicuous nucleoli. Within the solid areas the neoplasia shows morphologically features similar to clear cell renal cell carcinoma

Renal Cell Carcinoma ( Clear cell type ). Lymphocytic infiltration can be seen.

Clear cell carcinoma solid areas papillary structures cystic areas

Clear cell carcinoma. Furmahn grade2 .Adv ihc ck 7, vimentin& cd10

RCC clear cell variant with a papillary focus

Renal cell carcinoma of clear cell variant

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