Best test to diagnose cushing syndrome in children is: A. ACTH level B. CT scan of abdomen C. Steroid assay D. Dexamethasone suppression test

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Cushing’s Syndrome in Children The incidence of endogenous Cushing’s syndrome is approximately 2 to 5 new cases per million people per year, and approximately 10% of these new cases occur in children. The most common cause of endogenous Cushing’s syndrome in children is an ACTH-secreting pituitary adenoma (accounts for approximately 75% of all cases of endogenous Cushing’s syndrome in children older than 7 years) The most common cause of Cushing’s syndrome in infants and toddlers is an adrenal tumor (adenoma, carcinoma, or bilateral hyperplasia). Bilateral nodular adrenal disease is an ACTH-independent cause of Cushing’s syndrome. Children and adolescents with bilateral nodular adrenal disease may have periodic or “cyclic” Cushing’s syndrome. Bilateral nodular adrenal disease may be associated with genetic disorders such as Carney’s complex or McCune Albright Syndrome. Symptoms & Signs of Cushing’s in Children In many children the onset of Cushing’s syndrome may be insidious. Growth failure (or deceleration) associated with weight gain is a hallmark feature of Cushing’s syndrome in children. Other sign and symptoms often seen in children and adolescents with Cushing’s syndrome include facial plethora, increased fine downy hair on the face, body and extremities, a temporal fat pad, round face, diabetes and other symptoms listed below.

Thank you Sir, very informative

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