Concluded Case

blast phase of CML

45/female , known case of CML on Imatinib. developed pancytopenia and is persistent even after stopping imatinib. bone marrow aspiration- dry tap. bone marrow biopsy to rule out hypoplasia/ blast crisis. please give your valuable opinion.

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Concluded answer

BMBx : Hypercellular with increase in blasts,s/o Blast crisis.Impression: Evaluation of Cytopenias/Pancytopenia in a case of CML on Imatinib therapy progressed to Blast crisis. Refer : Indian journal of Hematology & Blood transfusion/Springer. Evaluation of Cytopenias Occurring in Imatinib Treated Chronic Myeloid Leukemia (CML) Patients T. Roshni Paul, Shantveer G. Uppin, [...], and Senthil J. Rajappa

All Answers

BMBx : Hypercellular with increase in blasts,s/o Blast crisis.Impression: Evaluation of Cytopenias/Pancytopenia in a case of CML on Imatinib therapy progressed to Blast crisis. Refer : Indian journal of Hematology & Blood transfusion/Springer. Evaluation of Cytopenias Occurring in Imatinib Treated Chronic Myeloid Leukemia (CML) Patients T. Roshni Paul, Shantveer G. Uppin, [...], and Senthil J. Rajappa

Thank you mam for your valuable opinion.
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Marrow appears normocellular to hypercellular Blasts are increased No fibrosis seen Possibilities Blast crisis Transformation to acute leukemia Adv IHC

Valuable opinion
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Hyper cellular marrow with increase of blast cell seen Impression is : CML with BLAST CRISiS

Valuable opinion
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@dr. Neelam sreemani mam