Dear Friends, Today's discussion is… impact of OBESITY on ASTHMA Obesity was defined as a body mass index (BMI) greater than 30 Studies show that obesity is a risk factor for asthma. There is a positive correlation between baseline body mass index and the subsequent development of asthma. factors which explain this association… (1)Obesity is capable of reducing pulmonary compliance, lung volumes, and the diameter of peripheral airways. (2)Obesity affects the volume of blood in the lungs and so leads to ventilation-perfusion mismatch. (3)The increase in the adipose tissue in obese subjects leads to a rise in the serum concentrations of several cytokines, the soluble fractions of their receptors, and chemokines. (4)Many of these mediators are synthesized and secreted by cells from adipose tissue and receive the generic name of adipokines, including IL-6, IL-10, eotaxin, tumor necrosis factor-alpha, transforming growth factors-beta1, C-reactive protein, leptin, and adiponectin. (5) Comorbidities associated with Obesity like Diabetes, OSAS and Gastroesophageal reflux  aggravates the Asthma further. Most studies point out that obesity is capable of increasing the prevalence and incidence of asthma, The treatment of obese asthmatics must include a weight control program. Studies suggest weight loss improves the course of Asthma I hope this piece of information will be HELPFUL Thanks Dr K N Poddar

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Wonderful post Dr Poddar sir Obesity and asthma has genetic basis. Obesity is associated with low grade chronic inflammatory disease . Obesity is associated with insulin resistance Diabetes Non alcoholic fatty liver disease Atherosclerosis Hypertension Metabolic syndrome Gall stones Osteoarthritis Gout Heart disease Cancers of uterus, cervix,endometrium, ovaries, colon, breast, oesophagus, liver,gall bladder, pancreas, prostate, kidney etc. stroke Asthma Sleep apnea . Reduction of weight leads to regression of all the above. Thanks for sharing the evidence based post sir .

very explicit answer mam
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LEPTIN A HORMONE ELEVATED IN OBESE AND ASTHMATICS. LEPTIN IS SECRETED BY ADIPOSE TISSUE AND WHERE OBESITY TENDS TO MORE THE POSSIBILITY OF ASTHMA ACCELERATE.

Definitely helpful sir. In fact i am just back from a respiratory CME where the speaker said that chronic deconditioning in obese patients also contributes to asthma apart from the factors elucidated by you. Also obese asthmatics show lower response to inhaled corticosteroids, hence management of asthma becomes difficult in obese patients.

Thank you for accepting sir.
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very useful and always to be kept in mind while treating patients of asthama. Thank you Sir for post

obesity is one of the comorbidity which needs to be consider in asthma pt specially difficult to control one nice post Dr Poddar

very useful sir... easy understanding of correlation & thats why important to deal with it in management part...

very useful information dr poddar but use effective ayurveda medicine 1 tab medohar gogal two bd 2 tab kaf kuthar ras two bd 3 syp kankasav 10 ml two times daily 4 sheikh pachan churan one tea spon ate night with warm 5

Nice information Sir Thanks

Very useful post Dr Poddar. Thanks

Informative

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