Discuss the synthesis,receptors, and termination of action of the neurotransmitter dopamine?.

1 Like


CONCLUSION. Synthesis of catecholamines 1.Tyrosine 》L- hydroxyphenylakanine ( L- DOPA) via tyrosine hydroxylase( TH) 2 L - DOPA》 dopamine via DOPA decarboxylase 3 Dopamone》 norepinephrine via dopamine beta -hydroxylase( DBH) 4 Norepinephrine 》 epinephrine via phenylethanolamine N methyltransferase( PNMT) RECEPTORS Five types of dopamine receptors ( D1 to D5 ) have been identified ,each exhibiting a distinct pharmacological profile as well as unique neuroanatomic distribution. TERMINATION OF ACTION. The action of dopamine is terminated preliminary by uptake via specific transporters.Dopamine is also inactivated by metabolism, intracellular dopamine is oxidative determined by monoamine oxidase to homolalinic acid ( HVA),and extracellular dopamine is methylated by catachol O methylteasferase( COMT) to produce dihydroxyphenylacetic acid( DOPAC)