HOW EFFECTIVE FOSPHENYTOIN IN COMPARISON TO PHENYTOIN IN NEONATAL SEIZURE AND DOSE

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fosphenytoin is a parenterally administered prodrug of phenytoin . can b given intramuscular too n rapid infusion can given too . 75 mg of fosphenytoin is equivalent to 50 mg of phenytoin . local tissue reaction cardiac toxicity like arrhythmia n hypotension are less compared to phenytoin . dose is same

Fosphenytoin does not cause the same degree of hypotension or cardiac abnormalities, soft tissue injury as compared to phenytoin. Dose-1.5 mg/kg fosphenytoin= 1 mg/kg phenytoin.

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Agree with above 1. Rapid intravenous infusion 2. Less local and cardiac toxicity 3. Phenytoin 1mg/kg 4. Fosphenytoin 1.5 mg/kg