Scripps Research Institute - FLORIDA- (USA) Research- Delivered to press on June 12 - 2020 Link - https// . Authors- Hyeryun Choe and Michael Farzan. TITLED - The D614G mutation in the SARS- COV- 2 spike protein reduces S1 shedding and increases infectivity IN a cryogenic electron microscope image of a SARS-CoV-2 spike protein side view, the S1 section of the spike is shown in green and the S2 portion is shown in purple. This unique two-piece system has shown itself to be relatively unstable. A new mutation has appeared in the viral variant most common in New York and Italy that makes this spike both more stable and better able to infect cells. (Credit: Andrew Ward lab, Scripps Research) Mutated coronavirus shows significant boost in infectivity JUPITER, FL — A tiny genetic mutation in the SARS coronavirus 2 variant circulating throughout Europe and the United States significantly increases the virus’ ability to infect cells, lab experiments performed at Scripps Research show. “Viruses with this mutation were much more infectious than those without the mutation in the cell culture system we used,” says Scripps Research virologist Hyeryun Choe, PhD, senior author of the study. The mutation had the effect of markedly increasing the number of functional spikes on the viral surface, she adds. Those spikes are what allow the virus to bind to and infect cells. “The number—or density—of functional spikes on the virus is 4 or 5 times greater due to this mutation,” Choe says. The spikes give the coronavirus its crown-like appearance and enable it to latch onto target cell receptors called ACE2. The mutation, called D614G, provides greater flexibility to the spike’s “backbone,” explains co-author Michael Farzan, PhD, co-chairman of the Scripps Research Department of Immunology and Microbiology. More flexible spikes allow newly made viral particles to navigate the journey from producer cell to target cell fully intact, with less tendency to fall apart prematurely, he explains.   “Our data are very clear, the virus becomes much more stable with the mutation,” Choe says. There has been much debate about why COVID-19 outbreaks in Italy and New York have so quickly overwhelmed health systems, while early outbreaks in places like San Francisco and Washington state proved more readily managed, at least initially. Was it something about those communities and their response, or had the virus somehow changed? All viruses acquire minute genetic changes as they reproduce and spread. Those changes rarely impact fitness or ability to compete. The SARS-CoV-2 variant that circulated in the earliest regional outbreaks lacked the D614G mutation now dominating in much of the world. But was that because of the so-called “founder effect,” seen when a small number of variants fan out into a wide population, by chance? Choe and Farzan believe their biochemical experiments settle the question




Educational post dr yograj nice up date Plse continue in.future also Thanks

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Informative article sir Thanks

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The cryogenic electron microscope image of mutated SARS-CoV-2 could not be posted due to no permission to reprint it - but the description of the mutated virus is there in the first paragraph of post. The picture posted is the latest electron microscope image of SARS-CoV-2- which has not relevant to the mutated virus

Informative post

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