ORAL GLP AGONIST SEMAGLUTIDE
SEMAGLUTIDE.. Rybelsus... ORAL GLP1 AGONIST APPROVED BY FDA!!! The U.S. Food and Drug Administration today approved Rybelsus (semaglutide) oral tablets to improve control of blood sugar in adult patients with type 2 diabetes, along with diet and exercise. Rybelsus is the first glucagon-like peptide (GLP-1) receptor protein treatment approved for use in the United States that does not need to be injected. GLP-1 drugs are non-insulin treatments for people with type 2 diabetes. Type 2 diabetes is the most common form of diabetes, occurring when the pancreas cannot make enough insulin to keep blood sugar at normal levels. GLP-1, which is a normal body hormone, is often found in insufficient levels in type 2 diabetes patients. Like GLP-1, Rybelsus slows digestion, prevents the liver from making too much sugar, and helps the pancreas produce more insulin when needed. In the placebo-controlled studies, Rybelsus as a stand-alone therapy resulted in a significant reduction in blood sugar (hemoglobin A1c) compared with placebo, as determined through HbA1c tests, which measure average levels of blood sugar over time. After 26 weeks, 69% of those taking 7 mg once daily and 77% of those taking 14 mg once daily of Rybelsus decreased their HbA1c to lower than 7%, compared with 31% of patients on placebo. The prescribing information for Rybelsus includes a boxed warning to advise health care professionals and patients about the potential increased risk of thyroid c-cell tumors, and that Rybelsus is not recommended as the first choice of medicine for treating diabetes. Patients who have ever had medullary thyroid carcinoma (MTC) or who have a family member who has ever had MTC are advised not to use Rybelsus. Additionally, patients who have ever had an endocrine system condition called multiple endocrine neoplasia syndrome type 2 (MEN 2) are advised not to use Rybelsus. Rybelsus is not for use in patients with type 1 diabetes and people with diabetic ketoacidosis. Rybelsus also has warnings about pancreatitis (inflammation of the pancreas), diabetic retinopathy (damage to the eye’s retina), hypoglycemia (low blood sugar), acute kidney injury and hypersensitivity reactions. It is not known whether Rybelsus can be used by patients who have had pancreatitis. The risk of hypoglycemia increased when Rybelsus was used in combination with sulfonylureas or insulin. Rybelsus should be taken at least 30 minutes before the first food, beverage or other oral medication of the day, with no more than 4 ounces of plain water. Rybelsus slows digestion, so patients should discuss other medications they are taking with their health care provider before starting Rybelsus. The most common side effects are nausea, diarrhea, vomiting, decreased appetite, indigestion and constipation. The approval of Rybelsus was granted to Novo Nordisk.
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A 45 yr female pt present with c/o uncontrol dm since 1 month rt hypochondriac region back headache gen weakness recently rbs 600mg/dl bp 160/90 mmHg k/C/O type 2 dm since 15 yrs Htn since 7 yrs ckd since 1 yrs diabetic retinopathy since 2 yrs please suggestions best opinion & Rx
Dr. Ruqqaiya Khan4 Likes16 Answers - Login to View the image
60 years old diabetic male patient comlaint of pus discharge from testicles wid fever ...rbs 540....second entry seen lowe side ....diagnosis?
Dr. Sunil Joshi4 Likes21 Answers - Login to View the image
70 yo man k/c/o dm & htn since 8 yrs. recently diagnosed with diabetic retinopathy. has on & off pain & swelling in rt foot phalenges only which comes back after stopping nsaids. x-ray shows no fracture.uric acid normal. 2d echo,Doppler right lower leg & ecg was done. serum creat,hgt, hba1c,lipid profile within normal limits.please interpret ecg n correlate with Doppler study & suggest further treatment
Dr. Priya Sonavdekar2 Likes22 Answers - Login to View the image
A 46 years old male admitted with complaint of weakness for 3 days with history of increased urination for last 3 weeks. On examination vitals stable. Admission RBS was 650mg/dl. ECG is attached. Diagnosis and management?
Dr. Suprabhat Giri8 Likes31 Answers - Login to View the image
45 y male Complain of breathlessness since two hours Known diabetic only in regular medications In arrival spo2 - 60% RA - bp 150/90 pulse 140 Temp normal Further management ??
Dr. Neeraj Mangla3 Likes18 Answers
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