ROLE OF Pirfenidone in COVID 19?
Pirfenidone.. used for pulmonary fibrosis treatment... But must be considered after 2 months ...
Pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone), is a novel anti-fibrotic agent with trivial adverse effects. Pirfenidone is approved for the treatment of Idiopathic Pulmonary Fibrosis (IPF) for patients with mild to moderate disease. Pirfenidone could inhibit apoptosis, downregulate ACE receptors expression, decrease inflammation by several mechanisms and ameliorate oxidative stress and hence protect pneumocytes and other cells from COVID-19 invasion and cytokine storm simultaneously. Based on the pirfenidone mechanism of action and the known pathophysiology of COVID-19, I believe that pirfenidone has the potential for the treatment of COVID-19 patients.
Definitely use in cases of Pulmonary fibrosis Routine use any chest physician can opion
AS IT.. INHIBIT .. APOPTOSIS.. IT PROTECTS.. PNEUMOCYTES AND OTHER CELLS.. FROM COVID-19..INVASION..
Cases that would interest you
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30 yrs female with severe dyspnoea and cough. Diagnose
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70yrsM Cough,SOB x 15days Took ATT for 8 months 9yrs back
Dr. Anwer N Jamali1 Like18 Answers - Login to View the image
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Dr. Niket Mantri1 Like18 Answers - Login to View the image
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Dr. Kunwar Yusuf9 Likes18 Answers - Login to View the image
Pt presented with progressive Dyspnea and dry cough from last 6 months . Clubbing present . Xray attached ( spotter)
Dr. Rishabh Goel5 Likes25 Answers