ROLE OF Pirfenidone in COVID 19?

LikeAnswersShare

Pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone), is a novel anti-fibrotic agent with trivial adverse effects. Pirfenidone is approved for the treatment of Idiopathic Pulmonary Fibrosis (IPF) for patients with mild to moderate disease. Pirfenidone could inhibit apoptosis, downregulate ACE receptors expression, decrease inflammation by several mechanisms and ameliorate oxidative stress and hence protect pneumocytes and other cells from COVID-19 invasion and cytokine storm simultaneously. Based on the pirfenidone mechanism of action and the known pathophysiology of COVID-19, I believe that pirfenidone has the potential for the treatment of COVID-19 patients.

Valuable opinion
1

View 3 other replies

Pirfenidone.. used for pulmonary fibrosis treatment... But must be considered after 2 months ...

AS IT.. INHIBIT .. APOPTOSIS.. IT PROTECTS.. PNEUMOCYTES AND OTHER CELLS.. FROM COVID-19..INVASION..

Definitely use in cases of Pulmonary fibrosis Routine use any chest physician can opion