UNCOMMON MANIFESTATIONS OF COVID 19
UNCOMMON MANIFESTATIONS of COVID-19 Recent findings suggest that a significant number of people with COVID-19 may experience digestive symptoms. New research data says that out of all the patients who approached for medical care half of them have come up with the symptoms of the digestive system, such as loss of appetite and diarrhea. As the world races to find the best ways to cope with the new coronavirus, researchers continue to contribute to our understanding of COVID-19, the disease that the virus causes. The exact symptoms are the main point of interest. As with many other viral infections, SARS-CoV-2 infections cause different symptoms in different people. But WHICH SYMPTOMS ARE THE MOST COMMON? According to information from the World Health Organization (WHO), three of the most common symptoms are fever, coughing, and some difficulty breathing. However, people with COVID-19 have reported many other symptoms, including digestive ones. While the WHO still consider digestive symptoms to be uncommon, a new study from the Wuhan Medical Treatment Expert Group for COVID-19 suggests that such symptoms may be more widespread than specialists had thought. Digestive symptoms in 50.5% of patients were observed. The expert group behind this new study — the findings of which appear in The American Journal of Gastroenterology — analyzed data from 204 people who received medical care for COVID-19 between January 18 and February 28, 2020. The patients had an average age of 52.9 years, and of the total, 107 were male and 97 female. When they presented to a hospital, 103 of the 204 people — or 50.5% — were experiencing digestive symptoms. The main symptom reported was diarrhea, and other symptoms included vomiting, in four individuals, and abdominal pain, in two. Moreover, the digestive symptoms among the larger group grew more severe as the severity of COVID-19 increased the researchers' report.
Everyday a new symptomology of COVID 19 has emerged , more cases are asymptomatic ,a great challenge ahead of researchers and clinicians , you are facing a known virus or chemical weapon changing his sign and symptoms regularly and constantly. Digestive symptoms are also a part of various other sings or symptoms .
It is a challenge to day to understand typical symptomology of covid19 As it is changing as the day passes Asymptomatic status gets evolved and comes with different presentation and on screening turns outs covid19
Investigations for new cases of IBD to be made after test of COVID-19 in cases of diarrhoea/ vomiting
Corona virus presence in water has been found in paris but not here so far. It is really hard for clinicians to differentiate between normal GE symptoms in such climate or is it due to corona. Thanks for posting
It is the vreat challengevtoDay of covid 19 symptomatology.Most of the cases are asmltyomatic and lresnt indifferent modes like ear infection,digesTive syptoms by way of gastro like symptoms emerging a great challenge fkr researchars as well as clinicians . You are facing to a known viras or chemical weapons changkng his signs and symltoms regularly and every day.
Very interesting points regarding this virus ,it will take a time to explore the new symptoms and signs for methodical study
Yes there might be diarrhoea. That's in some foreign countries they have found presence Corona Virus in Sewage water.
Are digestive symptoms present with common symptoms or only digestive symptoms in covid-19 positive patients ?
A bit of confusion, but is better if the new discovery goes on for clear managament.. Good posting Dr
Yes, it happens but it is seen abroad. No such patient has been seen here,
Cases that would interest you
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30 year old male, 10 day history of diarrhoea and reduced oral intake, presented with lethargy and ongoing abdominal cramps. No respiratory symptoms, but O2 sats noted to be on the lower side, exertional O2 sats dropped to 86%. No past medical history of note, normal white cell count, not lymphopenic, urea 18.9 mmol/L, creatinine: 489 µmol/L, amylase 600 (30-118), ALT: 65, CRP: 100, Trop I 267 (0-46). Chest X-ray as shown. What do you think the patient is suffered from?
Dr. Somi Suyal2 Likes17 Answers - Login to View the image
34yrs/M admitted with C/o Generalized bodyaches,3 day history of on and off fever which is temporarily relieved by paracetamol,Hypogastric pain,He also experienced nausea and vomitting with loss of appetite.NO PETECHIAE OR RASES present over body.He was tested negative for COVID 19 but positive for dengue.On day 2 admission patient developed dry cough and mild difficulty in breathing. NEED SUGGESTIONS? *Chief Complaints* Fever,bodyaches,NV, Abdomen pain *History* No relevant medical history *Vitals* BP - 120/80,HR -110,Temp -99°F,Spo2 -98% without O2 support,RR - 18 *Investigations* COVID - RT PCR - NEGATIVE DENGUE IGg - Positive Platelet counts -4000,Hb -12,TLC -12000 HRCT chest enclosed
Dr. Prashant Ved4 Likes16 Answers - Login to View the image
The severity of COVID-19 illness may be influenced by what researchers call "cytokine storms." In a new study, investigators assessed 522 COVID-19 patients, aged 5 days to 97 years, who were admitted to two hospitals in Wuhan, China, in December and January. The study also included a "control group" of 40 healthy people. Compared to the control group, 76% of COVID-19 patients had significantly lower levels of T cells -- a type of white blood cell that plays a crucial role in immune response against viral infections. Patients admitted to the intensive care unit had much lower T cell counts than those who didn't require ICU care. Patients over age 60 had the lowest T cell counts, the findings showed. And the T cells that did survive in COVID-19 patients were exhausted and unable to function at full capacity, the study authors said. COVID-19 patients also had high levels of cytokines -- a protein that normally helps fight off infection. Too many cytokines can prompt an excessive inflammatory response called a "cytokine storm," which causes the proteins to attack healthy cells. That suggests the new coronavirus does not attack T cells directly. Instead, it triggers the cytokine release, which results in the loss and exhaustion of T cells, according to the authors of the study published May 1 in the journal Frontiers in Immunology. The study results provide new clues on how to treat COVID-19, the researchers said. "We should pay more attention to T cell counts and their function, rather than respiratory function of patients," study author Dr. Yongwen Chen of Third Military Medical University in Chongqing, China, said in a journal news release. Chen added that "more urgent, early intervention may be required in patients with low T lymphocyte counts." In addition, he noted, future research should focus on pinpointing subgroups of T cells that may be most important in COVID-19, along with identifying drugs that boost T cell counts and functioning. Source-https://www.drugs.com/news/blood-count-may-offer-clues-covid-19-study-89971.html
Dr. Priyank Jha4 Likes10 Answers - Login to View the image
Saliva As Protective Shield Against SARS-Cov-2 Hyposalivation as a potential risk factor for a SARS‐CoV‐2 infection was discussed in an article published in Oral Diseases. Human saliva is a very complex fluid and plays a crucial role in the prevention of viral infections and protection against them, since it contains a large number of proteins and peptides with antiviral effects. Previous studies have documented the antiviral effects of some of those proteins against other coronaviruses. In addition, such proteins have been reported to inhibit the replication of other coronaviruses. According to the authors, it is therefore reasonable to assume that the protective effect of these salivary proteins against SARS-CoV-2 might be similar. Another previous study has suggested that hyposalivation could lead to acute respiratory infection, because the reduced saliva secretion may impair the oral and airway mucosal surface and may result in a decreased secretion of antimicrobial proteins and peptides. Thus, hyposalivation may expose patients to a higher risk of contracting SARS‐CoV‐2. However, the study authors acknowledge that further studies on this topic are needed to prove this hypothesis. Is mucosal immunity more important? Although several knowledge gaps about SARS-CoV-2 exist, it is clear that a vaccine is urgently needed to prevent infection and possible reinfection in the long term. A study published recemtly addressed the question of whether mucosal SARS-CoV-2 vaccines would be more effective than parenteral vaccines. Owing to their genetic similarity, the development of MERS-CoV and SARS-CoV-1 vaccines in recent years has provided important insights for the development of SARS-CoV-2 vaccines. In an experimental series of SARS-CoV-1/MERS-CoV vaccines, mucosal vaccination resulted in attractive protective correlates—even higher than with parenteral vaccines. Thus, the research of mucosal vaccine candidates should be encouraged for developing effective SARS-CoV-2 vaccines.
Dr. Prashant Ved4 Likes5 Answers - Login to View the image
3 year male child, fever with diarrhoea 5days rushes appear Dx and Rx
Dr. Raj Kumar Jatawat0 Like23 Answers
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