Why does splenomegaly happen in malarial disease?

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Tropical splenomegaly syndrome, also known as hyperreactive malarial splenomegaly, occurs due immunological over-stimulation to repeated attacks of malarial infection over a long period of time. Condition is usually seen in malaria-endemic areas like Africa and Indian subcontinent.. Spleen becomes enlarged during malaria because of filtering out of excessive destroyed RBC after the hemolysis and occurs not only during malaria, during many infectious/non infecious diseases following with the RBC hemolysis.

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SPLENOMEGALY OCCURS IN MALARIA MAINLY DUE TO FOLLOWING REASONS .In malaria- there is filtering out of excessive destroyed R.B.C's after haemolysis .The parasitized RBCs are entrapped in the spleen and a marked immunological response occurs. The spleen subsequently becomes very congested, soft and starts to increase in size.This occurs more commonly in non-immune individuals and can lead ,in some instances, to spontaneous rupture of the spleen.In endemic areas of malaria, sometimes, the spleen enlarges and causes a syndrome named tropical splenomegaly syndrome and recently given the name of hyperactive malaria splenomegaly.The cause of this syndrome is postulated to be due to an abnormal immunologic response..

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