11-beta-hydroxysteroid dehydrogenase deficiency type 1

Decreased activity of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 due to inactivating mutation(s) in the HSD11B1 gene. The condition is characterized by hyperandrogenism as a result of increased adrenocorticotropic hormone stimulation of the adrenal gland due to failure of cortisol-mediated down-regulation, and is clinically indistinguishable from H6PD deficiency.

Disease Alternative Name

11-beta-hydroxysteroid dehydrogenase type 1 deficiency
cortisone reductase deficiency type 2
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