Activated pi3k-delta immunodeficiency syndrome
An orally available selective inhibitor of the delta isoform of phosphatidylinositol 3-kinase (PI3-kinase subunit delta; PI3K-delta; PI3Kdelta), with potential antineoplastic activity. Upon oral administration, PI3K delta inhibitor SHC014748M selectively binds to and inhibits PI3K delta and prevents the activation of the PI3K/AKT signaling pathway. This decreases proliferation of and induces cell death in PI3K delta over-expressing tumor cells. PI3K delta also plays a key role in the B-cell receptor (BCR) signaling pathway and the proliferation of certain hematologic cancer cells. The targeted inhibition of PI3K delta is designed to preserve PI3K signaling in normal, non-neoplastic cells, thereby minimizing serious side effects.
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X-rays are commonly used in clinical practice to diagnose fractures. Characteristics of the fracture such as the type, deformity & soft tissue / joint involvement are used to guide management. Learn & update your basic radiological approach for “Bone Fractures” & interpretation knowledge & patient care approach with this post.
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F.60yrs. LBA with swelling of legs. 3months.
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Paratesticular tumours are masses of slow & indolent growth & in most cases of benign nature, in these cases the treatment of choice is simple extirpation of the lesion. A paratesticular mass may derive from a number of structures that surround the testis within the scrotum; most commonly, they derive from the spermatic cord. Dr. Vivek Jha is sharing a clinical case of "Large Paratesticular Growth" managed with surgical expertise by him. Share your views on the case & learn new things.
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Detecting early-stage lesions is challenging when deep fissures, tight interproximal contacts, and secondary lesions are present. Eventually, many lesions are detected only in the advanced stages of dental caries, leading to a more complicated treatment. Many studies have been proposed showing role of AI in diagnosing and treatment planning for many dental conditions. Read about the studies.
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Check how quickly can you solve these questions using your clinical knowledge. Solve & get a chance to be the top performer. We are Live Now.
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