Aminoacylase-1

Patient N (male, 56 year old) had the corona-virus infection last month and has recovered without any complications. You will still recommend that patient N get vaccinated.

Although psoriasis starts with the involvement of skin, but it cannot be limited to just a skin problem. It has been linked to a number of other diseases, especially metabolic derangements and arthritis. The disease carries a huge socio-economic burden, and the diagnosis of psoriasis is purely based on clinical features. Depending upon the type of psoriasis, onset may be abrupt or slowly progressive. The course of the disease in the same individual is not uniform over time. It cannot be classified based on a single factor and generally involves differentiation of lesions based on the morphology of the lesions, degree of inflammation, distributing patterns of the lesions, and the extent of body surface involvement. Please share your valuable insights on the various clinical manifestations of the disease......

Psoriasis is often associated with other comorbidities such as psoriatic arthritis, obesity, inflammatory bowel disease, diabetes, and cardiovascular disease. Psoriasis causes increased medical costs, work limitations, as well as productivity loss. This economic burden, along with reduction in quality of life in patients prompts the need for effective disease management. Widespread disease often requires systemic treatment due to the extent of BSA involvement. Guidelines recommend treatment with biologic agents or nonbiologic agents or phototherapy with ultraviolet B (UVB) or with psoralen plus ultraviolet A (PUVA) therapy. Guidelines suggest that physicians should balance the individual patient characteristics with side-effects when making therapeutic decisions. Please share your thoughts on the same......

Topical agents are the cornerstone of treatment, either alone, or in combination with phototherapy or systemic treatments for psoriasis. Topical therapy is the treatment of choice in patients with psoriasis affecting < 10% body surface area (BSA) or for psoriasis affecting sensitive areas such as face, flexures, and genitals. They are used intermittently or continuously but more potent agents should be used for a shorter duration to avoid the side-effects. Please share your experiences with topical therapy for patients with psoriasis......

she is suffering from this skin disease for last 4 years and they haven't given any treatment yet, she applied luliconazole for few weeks but nothing's ok with that. please suggest and Rx Dx...