Atherosclerosis-deafness-diabetes-epilepsy-nephropathy syndrome

A maternally inherited condition characterized by diabetes and sensorineural deafness with onset after the age of 20, caused by mutation(s) in one of several mitochondrial genes, most frequently the MT-TL1 gene, which encodes the mitochondrial transfer RNA for leucine. Some patients may have additional features observed in mitochondrial disorders, including pigmentary retinopathy, ptosis, cardiomyopathy, myopathy, renal problems, and neuropsychiatric symptoms.

Disease Alternative Name

midd syndrome
maternally transmitted diabetes with deafness
maternal diabetes and deafness syndrome
maternally inherited diabetes and deafness

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