Glioblastoma

The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)

Disease Alternative Name

spongioblastoma multiforme
gbm (glioblastoma)
cns
glioblastoma (gbm)
who grade iv glioma
grade iv astrocytic tumor
grade iv astrocytoma
grade iv astrocytic neoplasm
gbm
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Recent Cases of Glioblastoma

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Top Cases of Glioblastoma

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Concluded Case

23 yrs female,with rt fronto parietal Glioblastoma multiformes.MRI suggestive of rt PCA infarct,what could be the cause ...See More

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Concluded answer

Brain edema raised ICP and 2ndary vascular compromise and PCA infarction. Kernohan notch - a radiological findings due to midline shift due to mass effect resulting in compression of contralateral cerebral crust by tentorium cerebelli resu...


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DA

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