Glioblastoma

The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)

Disease Alternative Name

spongioblastoma multiforme

gbm (glioblastoma)

cns

glioblastoma (gbm)

who grade iv glioma

grade iv astrocytic tumor

grade iv astrocytoma

grade iv astrocytic neoplasm

gbm

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Recent Cases of Glioblastoma

Browse recently discussed Glioblastoma cases by specialists

Dr. Raj Sharma

Internal Medicine

Case of GBM

Chief Complaint A 58 yo male presents with on and off headache for 1 month duration. Examination Intracranial pressure raised, rest of the neurological examination is normal. History He is a mild smoker for the past 10 years...See More

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Dr. Vaibhav Goyal

General Surgery

Recurrent Glioblastoma

Chief Complaint A 63 y/o male presents with the complaint of headache. History 1 year back he came with headache for 1 month which was increased for 1 week. Examination at that time showed increased intracranial pressure. MRI sh...See More

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Top Cases of Glioblastoma

Selected by editors, top cases are known for unique problem or best solution

Dr. Tanish Wadhwa

Pathology

Case of glioblastoma - imaging and path slide

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Concluded Case

Dr. Archana Verma

Neurology

23 yrs female,with rt fronto parietal Glioblastoma multiformes.MRI suggestive of rt PCA infarct,what could be the cause ...See More

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Dr. Manorama Rajan

Top Neurologist of May

Brain edema raised ICP and 2ndary vascular compromise and PCA infarction. Kernohan notch - a radiological findings due to midline shift due to mass effect resulting in compression of contralateral cerebral crust by tentorium cerebelli resu...

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